OM Prakash.pmd
نویسندگان
چکیده
Metal complex of pioglitazone hydrochloride (PLZ) drug with Ni(II) ion is synthesized and characterized using analytical data, molar conductance, IR, UV-Vis, magnetic, mass spectral and XRD studies. From the analytical data, the complex is proposed to have general formula [(C 19 H 19 N 2 O 3 S)+ 2 Ni]2Cl-. The conductometric titration using monovariation method reveals that complex is L 2 M type. The molar conductance data indicates that the metal chelate is ionic. IR spectra show that PLZ is coordinated to the metal ions in which ligand molecules lie horizontally joining the central Ni(II) atoms. The electronic spectra and magnetic moment reveal that the chelate have tetrahedral geometry. Mass spectra is also used to confirm the proposed formula and the possible fragments resulted from fragmentation of PLZ and its Ni(II) complex. XRD data also used to calculate the various parameters like particle size, porosity, volume of unit cell and density.
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